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GW 441756

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Catalog No. T6052Cas No. 504433-23-2

GW 441756 is a specific Tropomyosin-related kinase A (TrkA) inhibitor with an IC50 value of 2 nM.

GW 441756

GW 441756

🥰Excellent
Purity: 99.8%
Catalog No. T6052Cas No. 504433-23-2
GW 441756 is a specific Tropomyosin-related kinase A (TrkA) inhibitor with an IC50 value of 2 nM.
Pack SizePriceAvailabilityQuantity
5 mg48 €In Stock
10 mg76 €In Stock
25 mg147 €In Stock
50 mg225 €In Stock
100 mg341 €In Stock
500 mg806 €In Stock
1 mL x 10 mM (in DMSO)54 €In Stock
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Purity:99.8%
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Product Introduction

Bioactivity
Description
GW 441756 is a specific Tropomyosin-related kinase A (TrkA) inhibitor with an IC50 value of 2 nM.
Targets&IC50
TrkA:2 nM
In vivo
GW441756 inhibits γH2AX production mediated by TrkA and apoptosis in cells overexpressing TrkA. It specifically blocks TrkA-induced cell death in a dose-dependent manner.
Chemical Properties
Molecular Weight275.3
FormulaC17H13N3O
Cas No.504433-23-2
SmilesCn1cc(\C=C2/C(=O)Nc3cccnc23)c2ccccc12
Relative Density.1.31 g/cm3 (Predicted)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 18.33 mg/mL (66.59 mM)
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM3.6324 mL18.1620 mL36.3240 mL181.6201 mL
5 mM0.7265 mL3.6324 mL7.2648 mL36.3240 mL
10 mM0.3632 mL1.8162 mL3.6324 mL18.1620 mL
20 mM0.1816 mL0.9081 mL1.8162 mL9.0810 mL
50 mM0.0726 mL0.3632 mL0.7265 mL3.6324 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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